Faculty of Sciences University of Lisbon
Campo Grande, Lisbon, Portugal
21 - 23 June 2018
The Workshop on Integrative Approaches in Neurodegeneration is organized in the frame of the activities of the FlySMALS consortium, funded by the 2013 JPND Transnational call for “European research projects for Cross-Disease Analysis of Pathways related to Neurodegenerative Diseases”, which will come to an end this year.
The workshop aims to disseminate and integrate the results of the research consortium with state-of-the-art research in the field, promoting the joint presentation and discussion of relevant research topics by a panel of international experts including members of other consortia funded through the same JPND call.
The workshop targets a broad audience of basic, experimental, computational and clinical scientists, in the spirit of the JNPD Cross-Disease Analysis call which aims to:
The workshop will bring together 20 invited speakers and 50 registered participants,
providing an ideal environment for dynamic interactions promoting the exchange of expertise across areas,
supporting the conceptual development of novel integrative research approaches that will contribute to the future progress
in neurodegenerative disease research. Participants will be able to present their work at a poster section and
through short talks from selected abstracts.
Join us in the wonderful city of Lisbon for an exciting inter-disciplinary
program at the forefront of neurodegenerative disease research!
9:30 - Reception and registration
10:15 - Opening session: Jörg Schulz & Margarida Gama-Carvalho
10:30 - 11:00 - Richard I. Morimoto, Northwestern University
The Stress of Misfolded Proteins in Aging and Neurodegenerative Diseases
11:05 - 11:35 - Claire Russell, Royal Veterinary College
In vivo drug discovery identifies a compound that reduces seizure-like activity in the zebrafish model of CLN2 disease
11:40 - 12:10 - Coffee-break
12:10 - 12:40 - Aaron Voigt, RWTH Aachen University
Drosophila as a model organism for neurodegenerative diseases
12:45 - 13:15 - Dora Brites, iMed, University of Lisboa
Astrocyte phenotypic diversity in amyotrophic lateral sclerosis and therapeutic opportunities
14:30 - 15:00 - David Van Vactor, Harvard Medical School / Okinawa Institute of Science and Technology (OIST)
Mutants Lacking Drosophila Smn Display SMA Disease-relevant Neuromuscular Defects that Can be Rescued by Elevation in Conserved Transynaptic Signaling Pathways
15:05 - 15:35 - Martina Hallegger, Ule Lab, University College of London
The intrinsically disordered region of TDP-43 is essential for gene regulation
15:40 - 16:10 - Florence Besse, Université Nice Sophia Antipolis
Regulating neuronal RNP granules in space and time
16:15 - 16:45 - Cláudio Gomes, BioISI, University of Lisboa
Neuroinflammation meets protein aggregation: the neuronal S100B alarmin is a calcium-tuned suppressor of Aβ aggregation
17:00 – 19:00 Coffee-break/Poster session
09:30 - 10:00 - Lawrence Rajendran, University of Zurich
Systems biology approaches identify nutrient sensing as a target mechanism for Alzheimer’s disease
10:05 - 10:35 - Javier De Las Rivas, University of Salamanca
Bioinformatics for the discovery of biomarkers: application to the identification of novel gene markers in Alzheimer's disease
10:40 – 11:10 - Coffee-break
11:10 - 11:40 - Sara Madeira, University of Lisboa
Predicting disease progression in Amyotrophic Lateral Sclerosis using time windows and progression patterns
11:45 - 12:15 - Martin Hofmann-Apitius, Fraunhofer SCAI
Integrative modeling and mining in neurodegeneration research: towards longitudinal understanding of disease mechanisms
14:00 - 14:30 - Tom Gillingwater, University of Edinburgh
UBA1/GARS-dependent pathways link spinal muscular atrophy and Charcot-Marie-Tooth disease
14:35 - 15:05 - Luis Pereira de Almeida, CNC, University of Coimbra
Neurodegenerative diseases: From common mechanisms to promising therapies
15:10 - 15:40 - Margarida Gama Carvalho, BioISI, University of Lisboa
Unravelling common pathways for motor-neuron degeneration in SMA and ALS
15:45 - 16:15 - Peter Heutink, DZNE-Tübingen
Risk and Modifying factors in Fronto Temporal Dementia (RiMod-FTD)
16:30 – 17:00 Coffee-break
17:00 - 17:15 - Joana Margarida Silva, ICVS, University of Minho
Chronic stress triggers Tau pathology through autophagy inhibition and induction of stress granules
17:20 - 17:35 - Maria L. Spletter, Ludwig-Maximilians-Universität München
Scaf6 (DmCHERP) regulates the development of muscle and neurons in Drosophila
17:40 - 17:55 - Luís Sousa, CEDOC, NOVA Medical School
Elucidating the role of Synucleins in retinal neurodegeneration in Parkinson’s disease, diabetes and ageing
18:00 - 18:15 - Richard Tuxworth, University of Birmingham
Suppression of the DNA damage response protects the nervous system from pathology
18:20 - 18:35 - Marie Bordone, iMM, University of Lisboa
Decoupling cellular composition and molecular alterations in Alzheimer’s and Parkinson’s brains
09:00 - 09:30 - Tiago Outeiro, University Medical Center Goettingen
Modulation of alpha-synuclein biology and pathobiology via posttranslational modifications
09:35 - 10:05 - Joachim Weis, RWTH Aachen University
RNA binding protein pathology in ALS and vacuolar myopathy
10:10 - 10:40 - Coffee-break
10:45 - 11:15 - Joaquim Ferreira, iMM, University of Lisboa
Why are we failing developing new medicines in neurodegenerative diseases?
11:20 - 11:50 - Jörg Schulz, RWTH Aachen University
Translating basic science into clinical applications – Opportunities and Pitfalls
12:00 Closing Remarks - Margarida Gama-Carvalho
| EARLY BIRD | LATE BIRD | |
|---|---|---|
| STUDENT | 100€ | 200€ |
| ACADEMIC (1) | 200€ | 400€ |
| INDUSTRY* | 350€ | 700€ |
(1) PhD holders
The registration will work on a "first-come, first-served" basis and will only be considered upon confirmation of payment.
The proof of payment must be sent to neurodegen@fc.ul.pt
Workshop fees will cover attendance for the 2 and a half days of the workshop,
including 5 coffee-breaks and two lunches,
with the possibility to present an oral or poster communication
(depending on selection by the scientific committee), and workshop materials.
*If you would like to have an exhibit stand and/or distribute company materials please contact us.
| DEADLINES | |
|---|---|
| ABSTRACT SUBMISSION | May 21st 2018 |
| EARLY BIRD REGISTRATION | June 8th 2018 |
| LATE BIRD REGISTRATION | June 8th to June 20th 2018 |
For additional information, please contact us.
The workshop is held at the Faculty of Sciences of the University of Lisbon (FCUL). Address: Campus FCUL, Building C6, Campo Grande. 1749-016 Lisboa Portugal
From the Airport take the metro's Red Line (direction: "São Sebastião"), change in "Alameda" station to the Green Line (direction: Telheiras) and get off at "Campo Grande" station (30 min + 5 min walk to the meeting).
Takes 15-20 minutes.
Taxi-Autocoope contact number: (+351) 217 932 756
Bus 750 (direction: Algés) takes 20 minutes.
If you arrive by train from a European country, you will get off at "Oriente" station. There take the subway (direction: "São Sebastião") and change at "Alameda" station to the Green Line (direction: "Telheiras") . Get off at "Campo Grande".
Take the "2ª Circular" exit to "Campo Grande - Cidade Universitária". There are public pay-and-display car parks nearby.
From other parts of Lisbon, we particularly recommend the use of public transportation. Buses stopping at FCUL: 7, 21, 31, 35, 36, 47, 64, 78, 83, 106, 108, 701, 738, 745, 750, 755, 767, 768, 777 - BUS - Carris. Nearest subway stations: "Campo Grande" (Green and Yellow lines) and "Cidade Universitária" (Yellow line) - Subway - MetroLisboa